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. 2018 Mar 1;34(1-2):40–51. doi: 10.1089/jop.2017.0023

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© Cheng-Wen Lin et al. 2018; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — Netarsudil dose-dependent lowering of IOP in rabbits and monkeys. Formulations containing 0.005% (rabbit only), 0.01%, 0.02%, or 0.04% netarsudil were administered once daily (AM) to 1 eye of each animal for 3 days, with the fellow untreated eye serving as the control. IOP was determined for both eyes before test article administration (time 0) and at times 1, 2, 4, 8, and 24 h (rabbits) or 4, 8, and 24 h (monkeys) after each morning dose on Day 1 and 3. (A) Changes in IOP for the treated eye relative to the untreated contralateral eye in Dutch Belted rabbits (n = 10/group). IOP reductions were statistically significant (P < 0.05) at all postdose time points. (B) Change in IOP in the netarsudil-treated eye relative to the untreated contralateral eye in Formosan Rock monkeys (n = 6/group). IOP reductions were statistically significant (P < 0.05) at all postdose time points. IOP, intraocular pressure.