FIG. 4.

Systemic injection of 10 mg/kg RGFP966 daily for 14 days does not induce gross toxicity to major organs. Mice were injected IP with 30% HPβCD 0.1 M acetate (pH 5.4) vehicle, 2 mg/kg RGFP966 (data not shown), or 10 mg/kg RGFP966 every day for 14 days. The (A, B) heart, (C, D) small intestine, (E, F) kidney, (G, H) liver, (I, J) lung, and (K, L) skin were then harvested, processed for paraffin embedding, sectioned, and stained with H&E stain. The pathology results describe no vacuolization, nuclear fragmentation, polymorphonuclear or other immune cell infiltration, abnormal morphology, structural disorder, or indication of a toxic environment in any of the RGFP966-treated mice when compared with vehicle-treated mice. Scale bar = 10 μm. IP, intraperitoneal.