Table 12:
Impact on Quality of Life—MRgFUS Thalamotomy Versus Sham
| Time Point | Mean Score (SD) | Mean Improvement vs. Baseline | P Value | ||
|---|---|---|---|---|---|
| MRgFUS | Sham | MRgFUS | Sham | ||
| Baseline | 42.6 (18.3) | 42.8 (19.5) | – | – | NS |
| 3 months | 23.1 (16.9) | 41.4 (19.4) | 46% | 3% | < .001a |
| 12 months | 21.7 (17.2) | NAb | 49% | NAb | NA |
Abbreviations: MRgFUS, magnetic resonance-guided focused ultrasound; NA, not applicable; NS, not significant; SD, standard deviation.
Note: Quality of life assessed via the Quality of Life in Essential Tremor (QUEST) questionnaire.
a
P value is for the between-groups difference at 3 months follow up.
b
After the 3-month blinded period, sham participants could cross over to receive MRgFUS thalamotomy. Only the within-group difference for the MRgFUS thalamotomy group was reported for the 12-month time point.
Source: Elias et al, 2016.38