Table 13:
Improvement in Quality of Life Observed in Cohort Studies of MRgFUS Neurosurgery
| Author, Year | N | Target | Baseline, Mean Score (SD) | Follow-Up | Post-treatment, Mean Score (SD) | Improvement | P Value |
|---|---|---|---|---|---|---|---|
| Zaaroor et al, 201745 | 18a | VIM | 44.8 (12.9) | 1 mo 6 mo |
13.1 (12.3) 12.3 (7.2) |
71% 73% |
< .001 < .001 |
| Schreglmann et al, 201742 | 6 | CTT | 50.5 (19.4) | 6 mo | 24.8 (11.4) | 52% | .046 |
| Elias et al, 201337,43,44 | 15 | VIM | 37 (NR) | 12 mo | 12 (NR) | 68% | .001 |
Abbreviations: CTT, cerebellothalamic tract; MRgFUS, magnetic resonance-guided focused ultrasound; NR, not reported; SD, standard deviation; VIM, ventral intermediate nucleus of the thalamus.
Note: Quality of life was assessed via the Quality of Life in Essential Tremor (QUEST) questionnaire.
a
There were 30 study participants, of whom 18 had essential tremor and 12 had either Parkinson's disease or tremor-dominant Parkinson's disease. The characteristics described reflect means, ranges, and proportions for the subset of participants with essential tremor.45