Table 25:
Health State Utility Parameters Used in the Economic Model
| Mean Utility | Standard Deviation | Sample Size | Source | |
|---|---|---|---|---|
| Health State | ||||
| Alive with disabling tremor (baseline) | 0.69 | 0.30 | 24 | Herceg et al, 201283 |
| Improved tremor, post-surgery (marked improvement) | 0.91 | 0.08 | 24 | Herceg et al, 201283 |
| Improved tremor, post-surgery (mild to moderate improvement) | 0.80 | – | – | Assumption: calculated as the average of baseline and marked improvement post-surgery |
| Tremor recurrence, no reoperation | 0.69 | 0.30 | 24 | Assumption: quality of life returns to baseline |
| Tremor recurrence, reoperation (marked improvement) | 0.91 | – | – | Assumption: same as no recurrence, marked improvement |
| Tremor recurrence, reoperation (mild to moderate improvement) | 0.80 | – | – | Assumption: same as no recurrence, mild to moderate improvement |
| Adverse Effect or Complication | ||||
| Gait disturbance | 0.82 | – | – | Yardley et al, 201284 |
| Paresthesia or numbness | 0.81 | – | – | Thoma et al, 200685 |
| Speech disorder | 0.54 | – | – | Tengs et al, 200086 |
| Headache | 0.77 | – | – | Tengs et al, 200086 |
| Infection | 0.64 | – | – | Lee et al, 201087; Gheorghe et al, 201588 |
| Intracranial hemorrhage | 0.60 | – | – | Lenert et al, 199789 |
| Lead fracture or device malfunction | 0.66 | – | – | Gada et al, 201290 |