Table 9:
Reduction in Functional Disability Observed in Nonrandomized Studies of MRgFUS Thalamotomy
| Author, Year (Study Design) | N | Intervention | Baseline Score, Mean (SD) | Follow-Up | Post-treatment Score, Mean (SD) | Improvement | P Value, Change From Baseline |
|---|---|---|---|---|---|---|---|
| Huss et al, 201540 (Retrospective analysis) |
15 13 57 |
MRgFUS Unilateral DBS Bilateral DBS |
18.2 18.9 19.9 |
NR | 2.8 3.2 2.3 |
85.4% 88.4% 83.1% |
< .05a < .05a < .05a |
| Elias et al, 201337,43,44 (Cohort) | 15 | MRgFUS | 18.2 (4.1) | 12 mo | 2.8 (3.4) | 85% | < .001 |
Abbreviations: DBS, deep brain stimulation; MRgFUS, magnetic resonance-guided focused ultrasound; NR, not reported; SD, standard deviation.
Note: Disability was assessed via part C of the Clinical Rating Scale for Tremors (CRST), where higher scores indicate greater severity. The maximum possible score is 32.
a
P values presented reflect change from baseline. In the study by Huss et al,40 the between-groups comparisons for degree of reduction in disability were not significant for the comparison of bilateral deep brain stimulation with either unilateral deep brain stimulation (P = .42) or MRgFUS thalamotomy (P = .59).