Table 1.
Significant Upregulated Genes Differentially Expressed in Human Neonatal Articular Cartilage Compared to Human Mesenchymal Stem Cell-Derived Three-Dimensional Cartilage
| Gene | dExp | d | Fold change | Gene | dExp | d | Fold change |
|---|---|---|---|---|---|---|---|
| MSMP | −0.38 | 2.98 | 170.4 | SCNN1A | −0.14 | 1.69 | 17.8 |
| CD79B | −0.31 | 2.70 | 98.9 | RNU105B | −0.13 | 1.69 | 17.2 |
| SNORD3C | −0.32 | 2.10 | 58.0 | TCEAL2 | −0.13 | 1.73 | 16.9 |
| RPS4Y1 | −0.21 | 2.45 | 56.1 | ALDH1L1 | −0.12 | 1.70 | 16.3 |
| UCMA | −0.19 | 2.37 | 53.6 | MATN1 | −0.12 | 1.66 | 15.7 |
| ITM2A | −0.20 | 2.40 | 50.9 | SOD3 | −0.12 | 1.67 | 15.5 |
| HBB | −0.21 | 1.69 | 45.8 | SPINT2 | −0.12 | 1.60 | 15.1 |
| SNORD3A | −0.45 | 1.89 | 42.8 | GRK5 | −0.16 | 1.58 | 14.7 |
| DLK1 | −0.26 | 1.90 | 41.3 | H19 | −0.34 | 1.32 | 14.4 |
| CD79B | −0.19 | 2.20 | 40.8 | SLITRK4 | −0.11 | 1.59 | 14.3 |
| HBA2 | −0.20 | 1.58 | 38.0 | COBLL1 | −0.18 | 1.42 | 14.3 |
| GPX3 | −0.63 | 1.93 | 36.7 | NFIB | −0.16 | 1.43 | 14.0 |
| PPP1R1B | −0.17 | 2.00 | 29.1 | COL11A2 | −0.24 | 1.31 | 13.8 |
| FRZB | −0.20 | 1.90 | 26.8 | STK32B | −0.13 | 1.44 | 13.5 |
| C2orf40 | −0.18 | 1.73 | 26.4 | TGFBR3 | −0.19 | 1.27 | 12.2 |
| CD14 | −0.17 | 1.76 | 22.2 | PHF17 | −0.13 | 1.47 | 12.0 |
| NDRG2 | −0.16 | 1.68 | 20.7 | ITGA10 | −0.28 | 1.39 | 11.6 |
| PNPLA7 | −0.16 | 1.78 | 19.5 | COL9A1 | −0.13 | 1.21 | 10.0 |
| SNORD3D | −0.33 | 1.49 | 19.2 | COL9A2 | −0.34 | 1.15 | 9.6 |
| PEG3 | −0.16 | 1.71 | 18.9 | FGF18 | −0.08 | 1.28 | 9.4 |
Analysis performed using a two-class unpaired SAM (Mev). Genes with a >9 fold change are shown. Gene names in bold letters have or may have a role during chondrogenesis.
dExp, expected score; d, observed score; SAM, significance analysis of microarray.