Table 2.

Significant Downregulated Genes in Human Neonatal Articular Cartilage Compared to Human Mesenchymal Stem Cell-Derived Three-Dimensional Cartilage

Gene	dExp	d	Fold change	Gene	dExp	d	Fold change	Gene	dExp	d	Fold change
COL10A1	−2.37	−20.98	0.0075	INSIG1	−0.19	−11.47	0.0682	FTHL3	−0.44	−8.27	0.1173
PENK	−2.16	−13.24	0.0087	FTHL8	−1.88	−7.74	0.0686	PMEPA1	−0.02	−5.69	0.1177
SPP1	−0.79	−13.47	0.0123	COL8A1	−0.26	−7.14	0.0743	FTH1	0.17	−7.40	0.1180
TACSTD2	−0.64	−9.91	0.0144	FABP5	0.29	−6.07	0.0762	FAM180A	3.02	−7.25	0.1191
CLEC3A	−1.69	−16.20	0.0148	FNDC1	0.13	−7.87	0.0790	CRYAB	−1.29	−6.48	0.1199
IBSP	−0.44	−11.62	0.0188	ID3	−0.28	−9.44	0.0793	HSPB1	−0.54	−5.04	0.1199
DPT	−0.82	−6.77	0.0203	GJA1	−0.38	−7.64	0.0795	GLRX	−0.51	−6.51	0.1248
DCN	−1.65	−8.11	0.0273	CXCL14	0.84	−9.00	0.0803	TGFBI	−1.98	−5.70	0.1291
PSAT1	−0.03	−12.04	0.0286	THY1	0.54	−9.10	0.0839	SERF2	−0.74	−6.38	0.1293
LUM	−0.26	−11.16	0.0289	KDELR3	0.35	−7.15	0.0842	FTHL11	−0.59	−6.78	0.1315
SLC7A5	−0.05	−7.76	0.0313	FTHL12	−1.85	−7.39	0.0845	SERF2	−0.74	−6.38	0.1293
CXCL13	0.11	−8.05	0.0316	ASNS	−0.02	−6.86	0.0862	FTHL11	−0.59	−6.78	0.1315
ALPL	−0.24	−7.01	0.0367	PTGES	0.06	−6.18	0.0878	NDUFB3	0.31	−5.65	0.1329
MGST1	0.05	−5.99	0.0385	KDELR3	0.03	−8.21	0.0934	MT1G	−0.02	−6.46	0.1334
P4HA2	−0.30	−10.34	0.0474	FTHL12	−1.71	−7.41	0.0978	PTH1R	−1.05	−7.92	0.1344
LOX	−1.64	−6.66	0.0502	FTHL2	−1.46	−8.35	0.0985	VKORC1	0.26	−7.19	0.1369
PANX3	−0.02	−8.35	0.0540	CA12	−0.27	−7.54	0.0990	FNDC1	0.78	−7.05	0.1370
MATN3	−0.72	−8.84	0.0553	C1QTNF3	1.67	−7.13	0.1017	DRD4	0.30	−6.33	0.1388
PPIC	0.04	−10.47	0.0556	CRYGS	−0.25	−7.65	0.1019	TMSB10	−1.97	−5.99	0.1390
CSRP2	0.32	−10.00	0.0566	ANGPTL2	0.10	−5.17	0.1030	THBS2	−0.25	−5.02	0.1394
RAB31	−0.51	−10.21	0.0582	ANGPTL7	−0.26	−5.59	0.1048	COL6A3	−1.36	−5.51	0.1476
RASL11B	0.29	−9.10	0.0585	NME1	−0.06	−5.20	0.1059	PPP1R14B	0.74	−6.94	0.1507
FABP5 L2	−0.36	−6.05	0.0610	ANXA2P1	−1.39	−6.95	0.1064	GNG11	0.37	−5.54	0.1516
FN1	1.61	−5.78	0.0614	EPDR1	0.49	−7.73	0.1074	CALU	0.31	−6.65	0.1664
ALCAM	4.33	−6.92	0.0619	PLOD2	0.03	−5.17	0.1077	CALD1	−0.03	−5.63	0.1682
PPIC	0.05	−9.65	0.0639	APCDD1 L	0.18	−5.02	0.1108	DCN	0.07	−4.91	0.1685
SERPINF1	0.41	−6.51	0.0659	SCD	−0.53	−6.99	0.1117	TMEM4	0.57	−5.89	0.1770
COL1A1	−1.86	−6.12	0.0659	SERPINE1	−0.27	−5.31	0.1122	FGFR3	0.16	−5.45	0.1818
POSTN	0.24	−6.96	0.0664	FABP5 L2	1.82	−5.68	0.1159	OSTC	0.02	−5.47	0.1849

Analysis performed using a two-class unpaired SAM (Mev). Gene names in bold letters have or may have a role during chondrogenesis.