Fig. 1. Schematic showing target protein-oriented natural product isolation by the Hes1 beads-HPLC method. (a) HPLC profile of a natural product extract; (b) incubation of the extract with Hes1 beads; (c) washing the beads and release of compounds from Hes1; (d) detection of the Hes1 binding natural product; (e) representation of the Hes1 glutathione Sepharose beads.
