Table 4.
Median and percentiles of NOAELs and LOAELs for maternal and developmental toxicity studies (OECD 414) in rabbits (measured in mg/kg/day).
| N | 5th | 10th | Median | 90th | 95th | |
|---|---|---|---|---|---|---|
| Oral: gavag | ||||||
| Maternal NOAEL | 81 | 5.2 | 12.65 | 100 | 1000 | 1600 |
| Maternal LOAEL | 17 | 7.5 | 19.75 | 125 | 337 | 549 |
| Developmental NOAEL | 87 | 10 | 22.8 | 250 | 1060 | 1600 |
| Developmental LOAEL | 10 | 15 | 15 | 50 | 250 | 250 |
| Oral: gavage, drinking water, feed and unspecifie | ||||||
| Maternal NOAEL | 86 | 4.3 | 11,5 | 100 | 1080 | 1600 |
| Maternal LOAEL | 17 | 7.5 | 19.75 | 125 | 337 | 549 |
| Developmental NOAEL | 93 | 10 | 24.3 | 232.5 | 1140 | 1600 |
| Developmental LOAEL | 10 | 15 | 15 | 50 | 250 | 250 |