Table 5.
Median and percentiles of NO(A)ELs and LO(A)ELs for maternal and developmental toxicity studies (OECD 414) in rabbits (measured in mg/kg/day).
| N | 5th | 10th | Median | 90th | 95th | |
|---|---|---|---|---|---|---|
| Oral: gavage | ||||||
| Maternal NO(A)EL | 95 | 4.75 | 10 | 100 | 1000 | 1600 |
| Maternal LO(A)EL | 19 | 7.5 | 9.75 | 125 | 546 | 620 |
| Developmental NO(A)EL | 104 | 10 | 21,6 | 215 | 1000 | 1600 |
| Developmental LO(A)EL | 11 | 15 | 16 | 65 | 250 | 250 |
| Oral: gavage, drinking water, feed and unspecified | ||||||
| Maternal NO(A)EL | 100 | 4 | 10 | 100 | 1000 | 1600 |
| Maternal LO(A)EL | 19 | 7.5 | 9.75 | 125 | 546 | 620 |
| Developmental NO(A)EL | 110 | 10 | 24 | 200 | 1000 | 1600 |
| Developmental LO(A)EL | 11 | 15 | 16 | 65 | 250 | 250 |