Table 8.
Median and percentiles of NO(A)ELs and LO(A)ELs for maternal and developmental toxicity studies (OECD 414) in rabbits (measured in mg/kg/day) combined BASF and REACH datasets.
| N | 5th | 10th | Median | 90th | 95th | |
|---|---|---|---|---|---|---|
| Oral: gavage | ||||||
| Maternal NO(A)EL | 135 | 5 | 10 | 100 | 1000 | 1300 |
| Maternal LO(A)EL | 51 | 10 | 20 | 110 | 536 | 1000 |
| Developmental NO(A)EL | 144 | 9.2 | 15 | 180 | 1000 | 1600 |
| Developmental LO(A)EL | 36 | 9 | 15 | 100 | 644 | 1000 |
| Oral: gavage, drinking water, feed and unspecified | ||||||
| Maternal NO(A)EL | 140 | 5 | 10 | 100 | 1000 | 1600 |
| Maternal LO(A)EL | 51 | 10 | 20 | 110 | 536 | 1000 |
| Developmental NO(A)EL | 150 | 9.5 | 15 | 175 | 1000 | 1600 |
| Developmental LO(A)EL | 36 | 9 | 15 | 100 | 644 | 1000 |