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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neuropharmacology. 2017 Jun 27;126:281–291. doi: 10.1016/j.neuropharm.2017.06.028

Figure 2. Nicotine facilitates dopamine release in HR animals and suppresses dopamine release in LR animals.

Figure 2

(A) Representative traces showing the effects of nicotine on tonic (5 Hz) and phasic (100 Hz) stimulations in LR (left) and HR (right) animals. Following bath application of 500 nM nicotine, correlation analysis shows no relationship between response to novelty and dopamine release magnitude elicited by single pulse stimulations (B), 5 pulse 5 Hz stimulations (C) or 5 pulse 10 Hz stimulations (D). For phasic stimulations of 20 Hz (E) and 100 Hz (F) response to novelty positively predicted the effects of nicotine on dopamine release. (G) Tertiary split of the data into HR and LR revealed that nicotine had differential effects on tonic and phasic dopamine release between the two phenotypes whereby phasic stimulations were amplified in HR animals and both tonic and phasic stimulations were attenuated in LR animals. ##, p < 0.01 LR + Nicotine vs HR+Nicotine; #### p < 0.0001 LR + Nicotine vs HR + Nicotine; Δ, p < 0.05 vs pre-drug condition of respective group. N (number of rats) = 18.