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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neuropharmacology. 2017 Jun 27;126:281–291. doi: 10.1016/j.neuropharm.2017.06.028

Figure 3. Response to novelty predicts behavioral sensitivity to acute administration of nicotine.

Figure 3

(A) Locomotor activity in a novel environment (cm) correlates with total locomotion following a subsequent nicotine injection (0.4 mg/kg, s.c.). (B) Tertiary split of locomotor response to novelty showing the effect of nicotine on locomotor activity (cm) across time (5 minute bins) between HR and LR animals. (C) Average locomotor counts (cm) in 5 minute bins comparing pre- vs. post-nicotine injection in HR (green) and LR (blue) animals shows that LR animals exhibit a greater reduction in locomotor activity post-injection compared to HR animals. (D) Locomotor response to nicotine normalized to baseline (post-nicotine/pre-nicotine) for HR and LR animals shows that nicotine decreases locomotion significantly more in LR animals compared to HR animals. N (number of rats) = 17. Δ, p <0.05 vs predrug; *, p < 0.05 vs HR.