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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neuropharmacology. 2017 Jun 27;126:281–291. doi: 10.1016/j.neuropharm.2017.06.028

Figure 5. Differential effect of nicotine on dopamine release between HR and LR animals is due to β2 subunit containing nAChR blockade.

Figure 5

(A) Representative traces demonstrating a differential effect of the selective β2 subunit containing nAChR antagonist DhβE on tonic (5 Hz) and phasic (100 Hz) dopamine release between LR (left) and HR (right) animals. Following bath application of DhβE (500 nM) we found that response to novelty did not correlate with dopamine release for single pulse (B), 5Hz (C) or 10 Hz (D) stimulations. However there was a positive relationship between response to novelty and dopamine release under phasic conditions of 20 Hz (E) 100 Hz (F). (G) DhβE augments phasic dopamine release in HR animals without effecting release in LR animals. #### p < 0.0001 LR+DhβE vs HR+DhβE; Δ Δ Δ Δ, p < 0.0001 vs pre-drug condition of respective group. N (number of rats) = 8.