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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Neuropharmacology. 2017 Jun 27;126:281–291. doi: 10.1016/j.neuropharm.2017.06.028

Figure 6. Differential effect of nicotine on dopamine release between HR and LR animals is due to α6β2 subunit containing nAChR blockade.

Figure 6

(A) Representative traces demonstrating opposing actions of the α6 subunit containing nAChR antagonist α-Ctx on tonic and phasic dopamine signaling between LR (left) and HR (right) animals. (B–D) Response to novelty did not predict the effects of α-Ctx (100 nM) on dopamine release elicited by a single pulse, 5 Hz or 10 Hz stimulations. However we found that response to novelty positively predicted the effects of α6 subunit containing nAChR blockade on dopamine release elicited by 20 Hz (E) and 100 Hz (F) stimulations. (G) α-Ctx augments phasic dopamine release in HR animals and while suppressing release in LR animals. # p < 0.05 LR + α-Ctx vs HR + α-Ctx; ##, p < 0.01LR + α-Ctx vs HR+ α-Ctx. N (number of rats) = 11.