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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Neurol. 2018 Apr 9;305:97–107. doi: 10.1016/j.expneurol.2018.04.002

Figure 4. SNIRKO mice do not show morphological or physiological changes characteristic of PDN in murine models.

Figure 4

Two characteristic signs of PDN in mice include decreased IENFD and reduced NCV. Nerve fibers (arrows) that cross the dermal-epidermal border (white line) were quantified in both IRlox/lox (A) and SNIRKO mice (B). No significant differences were noted (C). Results were analyzed with a student’s t-test. n=4 IRlox/lox and n=4 SNIRKO. In addition, no differences were observed in either SNCV (D) or MNCV (E). Results were analyzed with a student’s t-test. n=24 IRlox/lox and n=23 SNIRKO.