Table 2.
Representative citrullinated proteins that have a SNP at the originating Arg residue
| UniProt ID | Cit. (Uniprot) | Natural disease causing variant | Cit (published) | Citrullinated peptide |
|---|---|---|---|---|
|
P02649 APOE |
no | • Hyperlipoproteinemia, R to C or S (residues 154,160,163,176) | yes | SELEEQLTPVAEET
ARLSK SWFEPLVEDMQ QWAGLVEK LEEQAQQIRLQAEAFQA LK |
|
P45379 TNNT2 |
no | • Cardiomyopathy, familial restrictive R to Q,W,L,C, or P(residues102,104,140,288) • Cardiomyopathy, dilated R to W or L (residues 141,151,215) |
yes | VLAIDHLNEDQL
EK YEINVL NRINDNQK |
|
P19429 TNNI3 |
no | • Cardiomyopathy, familial hypertropnic R to Q,G,P, or H (residues 141,145,162,186,204) • Cardiomyopathy, familial restrictive • R to W, or H (residues145,192) |
yes | ENREVGDW
K ESLDL AHLK NIDALSGMEG K VDEE YDIEAK |
Citrullination [Cit or ] = deimidation of the guanidino group of arginine side chains to form an ureido group and the non-standard amino acid citrulline. The modified (Cit) and unmodifed (R) peptides were observed by MS148