Table 4.
KEGG pathways of differentially expressed genes in cluster 1.
| KEGG Pathway | Genes | Gene Set | z-score |
|---|---|---|---|
| Alanine, aspartate and glutamate metabolism | 9 | 24 | 2.72 |
| Aldosterone-regulated sodium reabsorption | 14 | 33 | 3.96 |
| Allograft rejection | 10 | 29 | 2.56 |
| Antigen processing and presentation | 24 | 57 | 5.15 |
| Arginine and proline metabolism | 19 | 44 | 4.71 |
| Ascorbate and aldarate metabolism | 5 | 12 | 2.31 |
| Autoimmune thyroid disease | 15 | 39 | 3.64 |
| Axon guidance | 6 | 97 | −2.83 |
| beta-Alanine metabolism | 9 | 20 | 3.38 |
| Biotin metabolism | 2 | 2 | 3.15 |
| Butanoate metabolism | 13 | 29 | 4.06 |
| Cell cycle | 7 | 111 | −3 |
| Citrate cycle (TCA cycle) | 17 | 29 | 6.05 |
| Collecting duct acid secretion | 8 | 21 | 2.62 |
| D-Arginine and D-ornithine metabolism | 1 | 1 | 2.23 |
| D-Glutamine and D-glutamate metabolism | 3 | 4 | 3.12 |
| Drug metabolism - cytochrome P450 | 17 | 49 | 3.38 |
| Drug metabolism - other enzymes | 10 | 30 | 2.43 |
| Fatty acid metabolism | 19 | 38 | 5.51 |
| Folate biosynthesis | 4 | 9 | 2.22 |
| Glutathione metabolism | 11 | 38 | 2.02 |
| Glycerolipid metabolism | 11 | 31 | 2.8 |
| Glycolysis / Gluconeogenesis | 17 | 48 | 3.48 |
| Glyoxylate and dicarboxylate metabolism | 6 | 10 | 3.66 |
| Graft-versus-host disease | 10 | 28 | 2.69 |
| Histidine metabolism | 8 | 22 | 2.46 |
| Limonene and pinene degradation | 5 | 8 | 3.46 |
| Lysosome | 27 | 95 | 3.07 |
| MAPK signaling pathway | 23 | 201 | −2.09 |
| Metabolic pathways | 216 | 806 | 8.65 |
| Metabolism of xenobiotics by cytochrome P450 | 13 | 46 | 2.1 |
| Natural killer cell mediated cytotoxicity | 21 | 80 | 2.29 |
| Nitrogen metabolism | 7 | 17 | 2.7 |
| Notch signaling pathway | 1 | 35 | −2.22 |
| Oocyte meiosis | 7 | 87 | −2.21 |
| Oxidative phosphorylation | 28 | 99 | 3.1 |
| p53 signaling pathway | 3 | 53 | −2.18 |
| Parkinson’s disease | 23 | 94 | 2.02 |
| Pathways in cancer | 32 | 262 | −2.06 |
| Pentose and glucuronate interconversions | 6 | 13 | 2.84 |
| Peroxisome | 27 | 64 | 5.49 |
| Phenylalanine metabolism | 6 | 13 | 2.84 |
| PPAR signaling pathway | 19 | 54 | 3.64 |
| Primary bile acid biosynthesis | 6 | 11 | 3.36 |
| Propanoate metabolism | 15 | 26 | 5.6 |
| Proximal tubule bicarbonate reclamation | 13 | 20 | 5.78 |
| Pyruvate metabolism | 14 | 32 | 4.1 |
| Retinol metabolism | 15 | 34 | 4.28 |
| Shigellosis | 3 | 53 | −2.18 |
| Spliceosome | 7 | 104 | −2.78 |
| Steroid hormone biosynthesis | 12 | 35 | 2.78 |
| Tryptophan metabolism | 16 | 28 | 5.73 |
| Tyrosine metabolism | 11 | 30 | 2.92 |
| Ubiquitin mediated proteolysis | 10 | 107 | −2.09 |
| Valine, leucine and isoleucine degradation | 22 | 39 | 6.66 |
| Wnt signaling pathway | 6 | 108 | −3.17 |