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. Author manuscript; available in PMC: 2019 Feb 20.
Published in final edited form as: Free Radic Biol Med. 2017 Dec 29;116:1–10. doi: 10.1016/j.freeradbiomed.2017.12.034

Figure 3.

Figure 3

In vivo tumoricidal effects of NIR PIT. (A) Morphological change in NIR PIT treated tumor cells. Hematoxylin and eosin staining for untreated and NIR PIT treated H520 tumor cells (top row) and untreated and NIR PIT-treated A431 tumor cells (bottom row). Membrane rupture is indicated by the black arrow. (B) Tumor growth plot for A431 tumors. Closed squares: Pan-IR700 with NIR PIT (n = 5), open squares: Pan-IR700 only (n = 5), and open circles: no treatment (n = 5). (C) Kaplan-Meier survival curve. Solid line: no treatment (control), dashed line: Pan-IR700, and dotted line: Pan-IR700 with NIR PIT. A statistically significant difference between the control group and the NIR PIT group was observed by a log-rank test (p = 0.001).