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. Author manuscript; available in PMC: 2019 Feb 20.
Published in final edited form as: Free Radic Biol Med. 2017 Dec 29;116:1–10. doi: 10.1016/j.freeradbiomed.2017.12.034

Figure 5.

Figure 5

Change in T2*-weighted sequential MRI and R2* during and after NIR PIT. (A) Design of the MRI experiment. (B) Anatomical image and temporal change in T2*-weighted images for NIR-treated (top rows, n = 6) and Pan-IR700/NIR PIT-treated (bottom rows, n = 5) tumors. Representative images are shown for both H520 (top panel) and A431 (bottom panel) tumors. T2*-weighted images are processed to show the percentage changes (−20% to +20%) from the average image acquired in the baseline scan (0–2 min). (C) Plot of change in R2* in tumor area over time. NIR PIT affected the R2* in EGFR-targeted A431 tumor cells but not non-targeted H520 cells.