Table 3. Multivariable linear regression model to estimate associations with retinal nerve fiber layer thickness in the Gutenberg Health Study.

Effect	Estimate	p-value
Intercept:
Male, 40–49 years	125.74
Male, 50–59 years	124.63
Male, 60–69 years	121.83
Male 70–80 years	121.18
Female, 40–49 years	127.73
Female, 50–59 years	124.92
Female, 60–69 years	123.85
Female 70–80 years	119.59
Spherical equivalent (per dioptre)	1.33	<0.0001
Intraocular pressure (per mm Hg)	-0.08	0.28
Axial length (per mm)	-1.29	<0.0001
Central corneal thickness (per μm)	0.0001	0.99
Pseudophakia (yes)	-0.31	0.90
Eye surgery (yes)	2.24	0.31
Self-reported glaucoma (yes)	-7.69	<0.0001
Systolic blood pressure (mm Hg)	0.0006	0.98
Diastolic blood pressure (mm Hg)	-0.02	0.65
History of myocardial infarction	-1.04	0.53
History of stroke	-0.35	0.85
History of coronary artery disease	-0.07	0.96
History of peripheral artery disease	-0.70	0.54
History of tinnitus	1.38	0.04
History of migraine	0.07	0.90
History of apnoea	-1.70	0.05
Body length (per cm)	0.02	0.52
Body weight (per kg)	0.03	0.07
Cholesterol (per mg/dl)	-0.0008	0.89
HbA1c (per mg/dl)	-0.01	0.98
Glucose (per mg/dl)	0.006	0.73
Homocysteine (per mg/dl)	-0.10	0.05
ever smoked (yes)	-0.45	0.34
Diabetes (yes)	-1.28	0.20
Alcohol (yes)	0.12	0.83
Alcohol >10g/day (female) / >20g/day (male)	-1.46	0.02