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. 2018 Apr 9;11(4):dmm031542. doi: 10.1242/dmm.031542

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Ocular symptoms in FBN1 Het rabbits. (A) The appearance and anatomy of FBN1 Het rabbit eyes, showing the enophthalmus, eyelid abnormalities and microphthalmia. (B) Oxytalan staining and IHC show the presence of zonules (arrows) and decreased fibrillin-1 in zonules of FBN1 Het rabbits. cb, ciliary body; le, lens epithelium. (C) H&E stain showing the defect in corneal epithelium (arrows) in FBN1 Het rabbits. (D) Statistical comparison of the thickness of the corneal epithelium in FBN1 Het rabbits and WT controls. (E) H&E stain showing the defect in nonpigmented epithelium in the ciliary body (arrow) in FBN1 Het rabbits. (F) Statistical comparison of the thickness of nonpigmented epithelium in the ciliary body in FBN1 Het rabbits and WT controls. Data are presented as mean±s.e.m. and analyzed using Student's t-tests with GraphPad Prism software 6.0. **P<0.01. n=6. Scale bars: 1 μm.