Skip to main content
. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: J Endocrinol Diabetes. 2016 Mar 8;3(1):10.15226/2374-6890/3/1/00141. doi: 10.15226/2374-6890/3/1/00141

Figure 5.

Figure 5

A) Heat treatment (56 × 30 mins) in depolarizing protein- A-eluates from diabetic nephropathy/nonischemic cardiomyopathy or depression caused gain in N2A neurite outgrowth inhibition;

B) elution profile of neurite-inhibitory activity in the heat-treated diabetic nephropathy/nonischemic cardiomyopathy protein- A-eluates following gel filtration on Sephadex G75 as described in Methods. A) Data are mean + SE; * P < 0.05 comparing activity in depolarizing eluates before and after heating; or comparing (depolarizing vs non-depolarizing) eluates before; or after heating. B) Similar results were obtained following gel filtration of the heat-treated Pt 11 protein-A-eluate or unheated protein-A-eluate from a diabetic schizophrenia patient with nephropathy and dementia.