. Author manuscript; available in PMC: 2018 May 22.

Published in final edited form as: J Endocrinol Diabetes. 2016 Mar 8;3(1):10.15226/2374-6890/3/1/00141. doi: 10.15226/2374-6890/3/1/00141

Table 5.

Association between diabetic nephropathy having reducing glomerular filtration rate and the presence of lower molecular weight peak plasma IgG light chain components

Depression and/or Atrial fibrillation
	Without nephropathy	With nephropathy
	(N = 5)	(N = 4)	P-value^ˆ
Age (years)	70.4 ± 3	68.3 ± 4	0.47
Mean eGFR (mL/min/1.73 m²)	91.8 ± 23	38.1 ± 21	0.015
Average peak MW (kD)^*	21.2 ± 7.7	8.0 ± 0.96	< 0.0001
Amino acid sequence homology to kappa light chain^**	NT	100% (n = 1)^***

average peak molecular weight (MW) was determined by mass spectrometry as described in Materials and Methods.

^**

Amino acid sequence homology to human kappa light chain variable sequence was determined as reported in Materials and Methods.

^***

Pt 8: a 62-year-old man with diabetic nephropathy progressing to end-stage-renal-disease who had family history of diabetic chronic kidney disease. eGFR- estimated glomerular filtration rate.