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m6A and m6Am are the two 6mA (6-methyladenine)-containing nucleotides in mRNA. 6mA is found in two distinct epitranscriptomic modifications: m6A (N6-methyladenosine) and m6Am (N6,2´-O-dimethyladenosine). The methyl groups that are added enzymatically to alter the function of the nucleotide are shown in red. m6A is found in 5´UTRs, coding sequences, and 3´UTRs. m6Am is found in one place in mRNAs, the first encoded nucleotide, which is adjacent to the m7G (N7-methylguanosine) cap.
