Table 1.
Documented and putative m6A readers, writers, and erasers in different organisms.
| Organism | DF-like | DC1-like | DC2-like | METTL3 | WTAP | METTL14 | VIRMA (KIAA1429) | FTO | ALKBH5 |
|---|---|---|---|---|---|---|---|---|---|
| Homo sapiens | YTHDF1 | YTHDC1 | YTHDC2 | METTL3 | WTAP | METTL14 | VIRMA | FTO | ALKBH5 |
| YTHDF2 | |||||||||
| YTHDF3 | |||||||||
| Mus musculus | YTHDF1 | YTHDC1 | YTHDC2 | Mettl3 | Wtap | Mettl14 | Virma | Fto | Alkbh5 |
| YTHDF2 | |||||||||
| YTHDF3 | |||||||||
| Xenopus laevis | YTHDF1 | YTHDC1 | Predicted YTHDC2 (XP_018119820) | mettl3 | wtap | mettl14 | virma | fto | alkbh5 |
| YTHDF2 | |||||||||
| YTHDF3 | |||||||||
| Danio rerio | YTHDF1 | YTHDC1 | Predicted YTHDC2 (XP_017211699) | mettl3 | wtap | mettl14 | si:ch211-79l20.4 (orthologous region) | fto | alkbh5 |
| YTHDF2 | |||||||||
| YTHDF3 | |||||||||
| Drosophila melanogaster | CG6422 | YT521-B | Ime4 | Fl(2)D | Kar4 | Virilizer | |||
| Saccharomyces cerevisiae | MRB1 | Ime4 | mum2 | Kar4 | |||||
| Schizosaccharomyces pombe | Mmi1* | Ime4 | |||||||
| Arabidopsis thaliana | >10 proteins that contain a YTH domain | MTA | FIP37 | ||||||
*
does not bind m6A (Wang et al. 2016)