Acquisition of 0.1% saccharin and METH (0.02, 0.05, or 0.08 mg/kg/inf) self-administration across 15 daily sessions of training. Shown are the percent of rats meeting acquisition criterion for (A) 0.1% saccharin (n = 11-14/group), (B) 0.02 mg/kg/inf METH (n = 7-11/group), (C) 0.05 mg/kg/inf METH (n = 9-16/group), and (D) 0.08 mg/kg/inf METH (n = 9-17/group). The ratio of rats that acquired to the total number that completed training for each group is indicated next to the corresponding acquisition curve. *p< 0.05 adolescent- vs. adultonset;#p< 0.05 female vs. male.