Table 1.

Summary of correlation coefficients between predicted and experimental ΔΔG values by different scoring functions

Nmuta	Nsam b	CFol c	CBeA d	CDco e	CPro f	CProFol g	CBinX h
1	1131	0.457	0.272	0.056	0.675	0.738	0.738
2	195	0.178		−0.057	0.459	0.425	0.459
3 or more	76	0.046		0.015	0.406	0.319	0.406
All mixed	1402	0.445		0.183	0.651	0.658	0.691

^aN_mut: number of mutations involved in each sample.

^bN_sam: number of mutation samples.

^cC_Fol: correlation coefficient by FoldX.

^dC_BeA: correlation coefficient by BeAtMuSic.

^eC_Dco: correlation coefficient by Dcomplex.

^fC_Pro: Correlation coefficient using Profile-score.

^gC_ProFol: correlation coefficient by profile-score + FoldX.

^hC_BinX: Correlation coefficient by BindProfX that uses combined score (profile-score + FoldX) for single-mutation and profile-score for multiple-mutations.