Table 1.
Therapeutic chemical–disease pairs
Number of diseases | Number of chemicals | % Chemicals |
---|---|---|
1 | 13 972 | 39.27 |
2 | 6657 | 18.71 |
5 | 6605 | 18.56 |
10 | 3119 | 8.77 |
20 | 1980 | 5.56 |
30 | 804 | 2.26 |
40 | 513 | 1.44 |
50 | 300 | 0.84 |
60 | 245 | 0.69 |
70 | 196 | 0.55 |
80 | 151 | 0.42 |
90 | 111 | 0.31 |
100 | 104 | 0.29 |
110 | 93 | 0.26 |
120 | 58 | 0.16 |
130 | 54 | 0.15 |
140 | 58 | 0.16 |
150 | 44 | 0.12 |
160 | 44 | 0.12 |
170 | 33 | 0.09 |
180 | 29 | 0.08 |
190 | 24 | 0.07 |
200 | 26 | 0.07 |
210 | 30 | 0.08 |
220 | 27 | 0.08 |
230 | 32 | 0.09 |
240 | 16 | 0.04 |
250 | 15 | 0.04 |
300 | 51 | 0.14 |
>300 | 189 | 0.53 |
Total | 35 580 | 100.00 |
Over 13 000 chemicals have been tested on only one disease whereas 189 chemicals(the most highly repurposed chemicals according to the definition used here) have been tested for >300 diseases each.