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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Drug Discov Today. 2018 Jan 9;23(3):661–672. doi: 10.1016/j.drudis.2018.01.018

Table 7.

Drugs repurposed for migraine (counts are estimates)

Chemical Migraine article
counta 		First publication year of
treatment for any
diseaseb 		Publication year of first
migraine articlec
Ergotamine 202 1964 1965
Dihydroergotamine 129 1973 1976
Topiramate 109 1987 2002
Propranolol 101 1965 1968
Aspirin 99 1951 1974
Metoclopramide 86 1970 1974
Valproic acid 77 1973 1993
Acetaminophen 72 1948 1972
Naproxen 63 1974 1985
Indomethacin 54 1964 1968
Amitriptyline 33 1963 1969
Prochlorperazine 29 1964 1973
Cinnarizine 28 1973 1977
Diclofenac 28 1975 1979
a

Number of articles in which drug and migraine appear as drug–disease pair.

b

Year of publication in which drug appears in drug–disease pair with any disease.

c

Year of publication in which drug appears in drug–disease pair with migraine.