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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):850–856. doi: 10.1097/MPG.0000000000001887

Figure 4. Abnormal early histology in liver and biliary remnants.

Figure 4

(A-D) Liver. (A) Duct proliferation (brown) at DoL 15 (case 1, 100X, anti-CK7). (B) Reactive ducts/ductules (red) at DoL 30 (case 6, 200X, anti-CD56). (C) Bridging fibrosis (blue) at DoL 21 (case 4, 100X, trichrome). (D) Canalicular bile plugging (arrow) at DoL 24 (case 5, 400X, H&E). (E-F) Biliary remnants. Areas of left (E) and right (F) hepatic duct tissue devoid of large, epithelial-lined ducts at DoL 16. Some small duct branches with epithelial cells loss, distorted lumens, and circumferential fibrosis are seen (arrows) (case 2, 100X, H&E). Bar=100 uM.