Table 2.

Previously reported single nucleotide polymorphisms included in genetic risk scores for vertical cup-disc ratio

Chr	Nearest Gene	SNP	Alleles	VCDR- increasing allele	Frequency of VCDR-increasing allele	Weight	Reference
1	RERE	rs301801	T/C	C	0.21	0.008	10
1	RERE	rs12025126	T/C	T	0.59	0.011	9
1	RPE65	rs1925953	A/T	T	0.68	0.006	12
1	CDC7/TGFBR3	rs1192414	A/G	A	0.28	0.014	12
1	CDC7/TGFBR3	rs4658101	A/G	A	0.29	0.013	12
1	F5	rs10753787	T/C	C	0.75	0.007	12
3	FLNB	rs6764184	G/T	T	0.29	0.007	12
3	COL8A1	rs2623325	C/A	A	0.23	0.016	10
3	COL8A1	rs6804624	T/C	C	0.37	0.008	12
3	COL8A1	rs1997404	T/G	G	0.26	0.008	12
5	PDZD2	rs72759609	T/C	T	0.91	0.012	12
5	VCAN	rs7717697	T/C	T	0.64	0.007	12
5	DUSP1	rs17658229	T/C	T	0.99	0.02	10
5	DUSP1	rs114503346	C/T	C	0.99	0.021	12
5	DUSP1	rs35084382	T/C	T	0.99	0.018	12
6	EXOC2	rs17756712	A/G	G	0.18	0.01	10
6	RREB1	rs4960295	G/A	A	0.51	0.007	12
6	HSF2	rs868153	T/G	T	0.74	0.007	10
7	DGKB	rs10274998	C/T	T	0.41	0.008	12
8	CRISPLD1	rs117598310	G/T	T	0.05	0.009	12
8	PSCA	rs2920293	C/G	C	0.47	0.006	12
9	CDKN2B	rs1063192	G/A	A	0.81	0.014	9
9	CDKN2BAS	rs7865618	G/A	A	0.81	0.013	10
9	CDKN2B/AS1	rs2157719	C/T	T	0.81	0.013	12
9	CDKN2B/AS1	rs1360589	C/T	T	0.82	0.013	12
10	ATOH7	rs7916697	A/G	G	0.62	0.018	12
10	ATOH7	rs7916410	T/C	C	0.64	0.018	12
10	ATOH7	rs1900005	A/C	C	0.64	0.018	10
10	ATOH7/PBLD	rs1900004	C/T	C	0.64	0.013	9
10	PLCE1	rs3891783	C/G	G	0.37	0.007	12
10	PLCE1	rs1830890	A/G	G	0.28	0.006	12
10	PLCE1	rs7072574	G/A	A	0.28	0.009	10
10	ENO4	rs1681739	C/T	T	0.31	0.006	12
11	SCYL1	rs17146964	A/G	A	0.86	0.014	9
11	SSSCA1	rs1346	A/T	A	0.86	0.013	12
11	ADAMTS8	rs4936099	C/A	A	0.71	0.007	12
12	RPAP3	rs11168187	A/G	A	0.87	0.009	10
12	TMTC2	rs10862688	A/G	G	0.25	0.008	10
12	TMTC2	rs442376	T/C	C	0.60	0.011	12
12	TMTC2	rs482507	C/T	T	0.59	0.011	12
12	TMTC2	rs324780	G/A	A	0.61	0.011	12
12	FAM101A	rs7311936	G/C	G	0.67	0.006	12
13	DCLK1	rs7323428	G/T	T	0.31	0.007	12
13	DCLK1	rs1926320	T/C	C	0.32	0.012	9
14	SIX1/6	rs4901977	C/T	T	0.25	0.011	10
14	SIX6	rs4436712	G/T	T	0.34	0.009	12
14	SIX6	rs8015152	C/T	T	0.27	0.01	12
14	SIX1	rs10483727	T/C	T	0.35	0.012	9
14	SIX6	rs34935520	G/A	G	0.35	0.009	12
15	FAM169B	rs6598351	C/T	T	0.12	0.006	12
15	ASB7	rs60779155	G/A	A	0.34	0.01	12
15	ASB7	rs34222435	C/T	T	0.33	0.01	12
15	ASB7	rs4299136	G/C	C	0.33	0.01	12
16	SALL1	rs11646917	G/T	G	0.71	0.009	12
16	SALL1	rs4784295	C/G	C	0.18	0.009	12
16	SALL1	rs1345467	G/A	G	0.17	0.009	12
17	BCAS3	rs8068952	G/C	C	0.81	0.012	9
19	ARID3A	rs2159128	G/T	T	0.14	0.019	9
20	BMP2	rs6054374	C/T	C	0.46	0.007	10
20	BMP2	rs6054375	G/T	G	0.47	0.01	12
20	BMP2	rs6107845	G/A	G	0.48	0.009	12
22	CHEK2	rs1547014	T/C	C	0.67	0.013	10
22	CHEK2	rs5762752	C/G	G	0.65	0.011	12
22	CHEK2	rs5752773	G/C	C	0.67	0.012	12
22	CHEK2	rs738722	T/C	C	0.69	0.012	12
22	CARD10	rs2092172	G/A	A	0.18	0.009	12
22	CARD10	rs56385951	G/A	A	0.09	0.011	12
22	CARD10	rs5756813	G/T	G	0.41	0.008	10