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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Exp Eye Res. 2018 Mar 8;171:54–61. doi: 10.1016/j.exer.2018.03.007

Figure 2. Neither SARM1 deficiency or WldS expression alter RGC death after ONC.

Figure 2

A. Cell counts of cleaved caspase 3+ (cCASP3+) cells 5 days after ONC. Neither Sarm1 deficiency (Sarm1+/− or Sarm1−/−) nor WldS expression altered the number of dying RGCs compared to WT mice (n ≥ 6, All genotypes; P>0.05 for all comparisons). Note, cCasp3+ cells were not found in uninjured mice of any genotype (n ≥ 4 for each genotype). B. Representative images of flat mounted retinas labeled with TUJ1 from WT, Sarm1−/− and WldS mice. C. Cell counts of the number of TUJ1+ RGCs in sham-injured and ONC-injured conditions. Long-term RGC survival 14 days after ONC was not altered by SARM1 deficiency (n ≥ 5 for each genotype; P>0.05 for all comparisons; error bars, SEM).