Figure 5. SARM1 loss and Wld^S function in the same axon degeneration pathway.

To determine if SARM1 and WLD^S function in the same axon degeneration pathway, mice expressing Wld^S in a Sarm1-null background were generated. Axon degeneration was assessed by quantifying the maximal amplitude of the CAP 14 days after ONC. The data for Sarm1^−/− and Wld^S mice are the same as from Figure 1. The CAP amplitude of all genotypes was significantly reduced 14 days after ONC, however, and Sarm1^−/−, Wld^S, and Sarm1^−/−;Wld^S mice all had significantly higher CAPs compared to WT controls. There was no difference in CAPs from Sarm1^−/−;Wld^S mice compared to Wld^S or Sarm1^−/− mice (n ≥ 5 for each genotype and condition).