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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Immunol. 2018 Apr 27;200(11):3840–3856. doi: 10.4049/jimmunol.1601317

Figure 1. The mevalonate (MA) pathway.

Figure 1

Previous work has established that inhibition of HMGCR with a statin drug significantly reduces eosinophilic airway inflammation and AHR in experimental allergic asthma. To further elucidate the role of the FTase arm of the MA pathway in mediating type 2/Th2 inflammation, we utilized FTI-277 to inhibit FTase enzyme activity. GGTase and squalene synthase are the alternate arms of the MA pathway but were not assessed in this study. The chemical structure of the FTase inhibitor FTI-277 (a Ras CaaX motif peptidomimetic) is shown in the inset.