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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Apr 30;28(11):1992–1999. doi: 10.1016/j.bmcl.2018.04.066

Figure 5.

Figure 5

Overlay of Trp 7-halogenase PrnA (pink, PDB ID: 2JKC), Trp 6-halogenase SttH (cyan, PDB ID: 5HY5), and Trp 5-halogenase PyrH (yellow, PDB ID: 2WET). Residues 460-462 of SttH were mutated to modulate the regioselectivity toward the Trp substrate.