Fig. 3.

Single-column heatmaps describing the super- and sub-pathway terms that are enriched with metabolites strongly upregulated (red shades) and downregulated (blue shades) in (A-B) naked mole-rats relative to mice, (C-D) late-torpor relative to torpor-entrance in 13-lined ground squirrels, and (E-F) methionine-restricted relative to control-fed rats. Colors correspond to the -log10(FDR adjusted P-value) (termed P’) of the enrichment set analysis statistical test (see Methods) multiplied by the sign of the mean ln(fold-change) of metabolite abundance