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. 2018 May 23;8:8250. doi: 10.1038/s41598-018-26451-z

Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

Sundeep Chaitanya Vedithi 1,2,, Sony Malhotra 1, Madhusmita Das 2, Sheela Daniel 2, Nanda Kishore 3, Anuja George 4, Shantha Arumugam 2, Lakshmi Rajan 2, Mannam Ebenezer 2, David B Ascher 5, Eddy Arnold 6, Tom L Blundell 1,
PMCID: PMC5964081  PMID: 29789675

Correction to: Scientific Reports 10.1038/s41598-018-23423-1, published online 22 March 2018

This Article contains typographical errors.

In the Results section under subheading ‘Rifampin Binding in M. leprae RNAP’,

“As the activity of rifampin relies on its ability to induce a steric clash with the 5′-ribonucleotide, mutations that influence its orientation in the binding pocket might lead to reduction in these steric clashes resulting inseset_name sele rifampin resistance.”

should read:

“As the activity of rifampin relies on its ability to induce a steric clash with the 5′-ribonucleotide, mutations that influence its orientation in the binding pocket might lead to reduction in these steric clashes resulting in rifampin resistance.”

In the Discussion section,

“Lepromatous leprosy (LL) is characterized by high bacillary loads and low M. leprae specific cell-mediated immune responses32 in the host, increasing likelihood of the presence of bacterial persisters post-treatment which may adopt to rifampin by inducing point mutations with the RRDR.”

should read:

“Lepromatous leprosy (LL) is characterized by high bacillary loads and low M. leprae specific cell-mediated immune responses32 in the host, increasing likelihood of the presence of bacterial persisters post-treatment which may adapt to rifampin by inducing point mutations within the RRDR.”

Contributor Information

Sundeep Chaitanya Vedithi, Email: scv26@cam.ac.uk.

Tom L. Blundell, Email: tlb20@cam.ac.uk


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