Fig. 3. Increased sensitivity of DKO to IMQ-induced psoriasis correlates with decreased expression of GC targets.

a Score of scaling and erythema in CO, DKO, GR^EKO, and MR^EKO mice treated with imiquimod (IMQ) for 6 days. *, differences of DKO relative to CO; #, differences of DKO relative to GR^EKO; +, differences of DKO relative to MR^EKO; ·, differences of GR^EKO relative to CO; *^{, #, +, ·}p < 0.05; **^{, ##, ++}p < 0.01; ⁺⁺⁺p < 0.001; n > 5 mice per experimental group. b Representative images of skin sections of vehicle (V) and IMQ-treated mice that were H&E-stained or immunostained for Ly6G. Brackets: epidermal thickening; arrowheads, abnormal keratinocyte differentiation; and asterisks, immune infiltrates containing neutrophils. c–e Relative mRNA levels for indicated genes were quantitated by RT-QPCR in V and IMQ-treated skin of the indicate genotypes. *, comparison between treatments within one genotype; #, comparison between genotypes within the same treatment; *^{, #}p < 0.05, **^{, ##}p < 0.01, ***^{, ###}p < 0.001; n > 4 in each experimental group