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. 2018 May 22;8:8015. doi: 10.1038/s41598-018-25971-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Computational modeling of glucose consumption and lactate production in the gut MPS. Data-driven mechanistic modeling of glucose (black) and lactate (red) in the gut MPS for the 6-day, no medium change experiment. Measurements (symbols) and simulation (lines) of concentrations in the apical side (solid lines; circles) and basal side (dashed lines; squares) of the gut MPS are shown. Triplicates were pooled together due to low apical volumes.