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. 2018 May 22;9:2013. doi: 10.1038/s41467-018-04419-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Two-phase model for LAT activation. A model for LAT microcluster formation and maintenance using the two cellular pools of LAT is shown. a The left panel shows that at early time points, LAT vesicles decorated with VAMP7 are several microns away from the immune synapse, while plasma membrane-resident LAT can move laterally to be recruited to microclusters. The middle and right panels show that microtubule polarization toward the immunological synapse causes the reorientation of various vesicular compartments to the subsynaptic zone. b, c Zoomed-in regions of early and late stages of activation, respectively. b At early time points, plasma membrane LAT is recruited to microclusters and activated ZAP-70 phosphorylates LAT at the PM. c At later time points, LAT/VAMP7 vesicles are recruited to the immune synapse, move in a directed manner between microclusters, and interact dynamically with microclusters