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. 2018 May 16;9:1026. doi: 10.3389/fimmu.2018.01026

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Copyright © 2018 Olivares-Morales, De La Fuente, Dubois-Camacho, Parada, Diaz-Jiménez, Torres-Riquelme, Xu, Chamorro-Veloso, Naves, Gonzalez, Quera, Figueroa, Cidlowski, Vidal and Hermoso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dex and CD2-a Escherichia coli strains modulate gene expression in THP-1 macrophages. (A) Principal component analysis (PCA) from mRNA microarray performed on THP-1 macrophages. PCA shows the two main components, with CD2-a exerting more influence on variance as compared to Dex. (B) Cluster analysis of normalized samples. ANOVA (p < 0.05) and a cutoff of 1.5-fold change were used to select probes with statistical significance. Hierarchical clustering was performed based on 8,477 selected gene probes. (C) Venn diagram of the overlap in significant gene probes regulated by infection and/or Dex treatment. (D) Number of gene probes either induced (up) or repressed (down) by each condition.