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. 2018 May 16;9:1060. doi: 10.3389/fimmu.2018.01060

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Copyright © 2018 Langenhorst, Haack, Göb, Uri, Lühder, Vanhove, Hünig and Beyersdorf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD28 co-stimulation favors GATA-3 over T-bet expression in tetanus and diphtheria toxoid-specific human memory CD4⁺ T cells upon antigenic recall under Th2 conditions in vitro. Additional analysis of experiments presented in Figure 4. (A) Representative FACS data of GATA-3 and T-bet expression in CD4⁺ T cells cultured in the absence (red) or presence (blue) of CD28.3-Fab. (B) Normalized ratio of median fluorescence intensity (MFI) T-bet/MFI GATA-3 in proliferated CD4⁺carboxyfluorescein succinimidyl ester diacetate^low cells cultured under Th0 (left), Th1 (middle), or Th2 (right) culture conditions. Graphs show mean + SD from 19 donors assayed individually and tested with a one-tailed paired t-test (*p < 0.05, **p < 0.005).