Table 4.
Summary of macrophage, airway, lung tissue, and plasma exposures.
| Fold difference |
|||||
|---|---|---|---|---|---|
| IV Amikacin | Inh Amikacin | ALIS | ALIS vs. IV Amikacin | ALIS vs. Inh Amikacin | |
| Macrophages | 0.1 | 2.9 | 17.8 | 274.2 | 6.1 |
| Airways | 4.2 | 142.5 | 292.6 | 69.5 | 2.1 |
| Lung tissue | 162.1 | 2771.0 | 6917.0 | 42.7 | 2.5 |
| Plasma | 22.6 | 3.1 | 3.8 | 0.2 | 1.2 |
Values represent area under the curve (AUC) calculated for each group using the mean concentrations at each timepoint. AUC2-24 was calculated for macrophage, airway, and plasma exposures, whereas AUC0-24 was calculated for lung exposure.