Table 4.

Preclinical representation of several H3R antagonists in different animal models of SCH.

Ligand	Dose (mg/kg)	Species	Pharmacological effect observed	References
Thioperamide	10 and 30 (i.p.)	Mice	Increase of prepulse inhibition	Browman et al., 2004; Sadek et al., 2016
Ciproxifan	1, 3, and 10 (i.p.)	Mice	Increase of prepulse inhibition	Browman et al., 2004; Sadek et al., 2016
ABT-239	0.3-3.0 (i.p.)	Rats	Decrease of cognitive deficits induced by ketamine and MK-801	Brown et al., 2013; Sadek et al., 2016
A-431404	0.3-3.0 (i.p.)	Mice	Decrease of cognitive deficits induced by ketamine and MK-801	Browman et al., 2004; Sadek et al., 2016
SAR110894	0.3-3 (p.o.)	Mice	Decrease in Impaired social behaviors	Griebel et al., 2012; Sadek et al., 2016
	0.3-1 (p.o.)	Rats	Decrease in Impaired social behaviors	Griebel et al., 2012; Sadek et al., 2016