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. 2018 May 16;9:1018. doi: 10.3389/fmicb.2018.01018

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Copyright © 2018 Rabelo, Souza, Salomão, Oliveira, Sentinelli, Lacerda, Saraquino, Rosman, Basílio-de-Oliveira, Carvalho and Paes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of ZIKV antigens in fetal organs. (B,D,F,H,J,L,N,P,R,T) The flaviviral E and ZIKV-NS1 protein were detected in all tissues studied. (B,L) Microglial cells and neurons of the brain tissue were positive for ZIKV E protein and NS1, respectively. (D,N) ZIKV E and NS1 proteins were detected in alveolar macrophages. (F,P) Section of a skin dermis showed mononuclear cells of an inflammatory infiltrate and endothelial cells stained respectively to ZIKV E and NS1 proteins. (H,R) ZIKV E protein and NS1 detection in macrophages of the kidney. (J,T) Detection of ZIKV E protein and NS1 in hepatocytes, respectively. (A,C,E,G,I,K,M,O,Q,S) The E and NS1 antigens of ZIKV were not detected by immunohistochemistry in the control fetus.