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. 2018 May 16;9:1058. doi: 10.3389/fimmu.2018.01058

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Copyright © 2018 Dagher, Xu, Negoro, Khan, Feldman, Reedy, Tam, Sykes and Mansour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spleen tyrosine kinase is required for peritoneal macrophage control of Candida glabrata. (A) Differential interference contrast (DIC) and fluorescence microscopy image of carboxyfluorescein succinimidyl ester (CFSE)-C. glabrata and macrophage after 1 h of coculture indicating complete uptake of the yeast by the macrophages. Scale bar represents 50 μm. (B) DIC and fluorescence microscopy image of CFSE C. glabrata infected macrophages 16 h post inoculation. Macrophages control C. glabrata division in CFSE-bright undivided state, while treatment with R406 impaired the macrophages’ ability in controlling C. glabrata. Scale bar represents 5 µm. (C) Flow cytometry scatter plots of Con A and CFSE showing macrophage controlling C. glabrata division and loss of control in R406-treated cells. Data represent three independent experiments.