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. 2018 May 16;9:1058. doi: 10.3389/fimmu.2018.01058

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Copyright © 2018 Dagher, Xu, Negoro, Khan, Feldman, Reedy, Tam, Sykes and Mansour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spleen tyrosine kinase (Syk) is required at an early stage for macrophage control of Candida glabrata. Macrophages were treated with chemical Syk inhibitor, R406, prior to addition of C. glabrata for 2, 4, and 8 h after infection. All wells were lysed after 16 h of co-culture and the yeast retrieved and stained with ConA-AF647. Percent of parental CFSE-bright population was assessed via flow cytometry, with R406 treatments initiated at indicated time. **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. Data represent a minimum of three independent experiments.