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. 2018 May 16;11:155. doi: 10.3389/fnmol.2018.00155

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Copyright © 2018 Lu, Chen, Zheng, Li, Wang, Liu, Shi and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICA alleviated LID in 6-OHDA-lesioned rats. One, 7, 14 and 21 days after daily L-DOPA (25 mg/kg, i.p.) combined with ICA (20 mg/kg, p.o.) treatment, the effects of ICA on L-OHDA-induced changes of axial (A), limb (B) and orolingual (C) abnormal involuntary movements (AIM) scores were evaluated. The total AIM scores were also detected (D). The forepaw adjusting steps (FAS) test was applied to determine the effects of L-DOPA together with ICA on forelimb stepping changes (E). Data were shown as mean ± SEM from six rats (n = 6). ^#p < 0.05 compared with 6-OHDA-treated group;^Ψp < 0.05 compared with 6-OHDA+L-DOPA group.